Our Friend tells the inspiring and extraordinary true story of the Teague family - journalist Matt (Casey Affleck), his vibrant wife Nicole (Dakota Johnson), and their two young daughters - and how their lives are upended by Nicole's heartbreaking diagnosis of terminal cancer. As Matt's responsibilities as caretaker and parent become increasingly overwhelming, the couple's best friend Dane Faucheux (Jason Segel) puts his life on hold to stay with his friends, and the impact of this life-altering decision proves greater and more profound than anyone could have imagined.